Platelet-Rich Fibrin Matrix (PRFM)
PRFM is a more advanced version of PRP (Platelet-Rich Plasma) that builds on its natural healing benefits by adding a fibrin matrix. This matrix holds the platelets in place and gives extra support to the treated area. As a result, growth factors are released more gradually, helping boost collagen production, improve blood flow, and support long-term skin repair and renewal.
About PRFM
HOW IT WORKS
Unlike standard PRP, which is primarily a concentrated suspension of platelets and plasma, PRFM undergoes a unique processing technique that forms a three-dimensional fibrin scaffold. This fibrin matrix not only traps and holds the platelets in place but also provides structural support to the treated tissue. This structure allows for a slower, more sustained release of growth factors, including those that support collagen production and angiogenesis (the formation of new blood vessels), helping your skin heal, strengthen, and rejuvenate over time.
WHAT IT IS
PRFM is a next-generation, more advanced form of PRP (Platelet-Rich Plasma) that enhances the natural healing benefits of traditional PRP by incorporating a fibrin matrix.
WHAT TO EXPECT
Consultation:
Your treatment begins with a personalized consultation where your provider will assess your facial goals—such as volume loss, under-eye hollows, or fine lines—and determine if PRFM is right for you. A review of your medical history and skin health helps shape a safe, effective treatment plan tailored to your needs.
Preparation:
A small amount of blood is drawn from your arm, similar to a routine blood test. It is then processed in a specialized centrifuge that separates the platelets and creates a fibrin-rich matrix. While the PRFM is being prepared, the treatment area is cleansed and prepped, and a topical numbing cream or injected anesthetic may be used to ensure your comfort during the injection process.
Injection/Application:
Once the PRFM is ready, it is injected into targeted areas of the face using a fine needle or cannula—commonly under the eyes, in the cheeks, around the mouth, or along the jawline. The fibrin matrix acts as a scaffold, supporting tissue regeneration and long-term collagen stimulation.
During Treatment:
The procedure is typically very well tolerated. Patients may feel a slight sensation of coolness or gentle pressure, but PRFM injections are not usually painful. Most sessions take about 30 to 45 minutes, depending on the number of areas treated.
Aftercare:
Mild swelling, tenderness, or bruising at the injection sites is normal and usually resolves within a few days. You’ll be advised to avoid strenuous activity, direct sun exposure, and irritating or “antiinflammatory” skincare products for 24 to 48 hours. Avoid NSAIDs (i.e. Aspirin, Ibuprofen, Advil, Aleve, Excedrin) for 7-10 days following treatment as they can disrupt platelet signaling. Avoid icing the treatment area. Do not press or massage the injection sites for several days following the procedure. Your provider may give you other specific aftercare guidelines based on your treatment area.
Follow-Up:
Because PRFM gradually releases growth factors over 7–10 days, results appear progressively. For best results, most patients undergo a series of 2–3 treatments spaced 4–6 weeks apart, with maintenance sessions once or twice a year depending on your skin’s needs and aging goals.
BENEFITS OF PRFM
Improved skin color, texture, and tone
Reduced wrinkles, fine lines, dark spots, and scars
Increased collagen production
Enhanced skin health and appearance
FAQS
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Pain tolerance varies, but most patients report only mild discomfort during the PRFM treatment. If needed, numbing agents will be applied to the treatment area to minimize discomfort. While you may feel a slight sensation during the injection, it is typically well-tolerated. After the procedure, some patients may experience temporary redness, swelling, or bruising, which usually resolves quickly.
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The downtime after PRFM treatment is minimal. Most patients experience mild redness, swelling, or tenderness at the injection sites, which generally subside within a few days. You can resume normal activities immediately after the procedure, but it is advisable to avoid strenuous exercise and sun exposure for at least 24 to 48 hours.
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Results from PRFM can vary depending on factors such as skin type, lifestyle, and the extent of initial treatment. Patients typically see improvements in skin texture, tone, and firmness for several months after the procedure. Collagen production peaks around 2-4 weeks post-therapy and continues for up to 6 months. Periodic maintenance treatments may be recommended to sustain and enhance the benefits.
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Common side effects include temporary redness, swelling, and mild tenderness at the injection sites. These effects are usually mild and resolve on their own within a few days. It is important to discuss any concerns or medical conditions with your practitioner before undergoing the treatment.
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We recommend a series of 3 treatments for facial rejuvenation spaced 1 month apart. For acne scars, we recommend starting with a series of 5 treatments spaced 1 month apart. A maintenance session is typically recommended every 6-12 months.
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Most patients see signs of improvement after 1 week. Collagen takes 4-6 weeks to form, so many patients notice more dramatic results at that point.
Experience the transformative benefits of PRFM and achieve more radiant skin.
Contact Aligned Aesthetics Co. today to schedule your consultation and begin your journey to natural skin rejuvenation and renewed confidence.
Disclaimer: Our services are intended to support general wellness and should not replace professional medical advice, diagnosis, or treatment. Results may vary based on individual circumstances. Consult a qualified healthcare provider to determine if these treatments are appropriate for you. Any information provided is for educational purposes only and is not intended as a substitute for advice from a healthcare professional. Prescription services require a consultation with a licensed provider. Weight loss results depend on multiple factors, including lifestyle changes such as diet and exercise. Please follow all provider instructions to achieve optimal results.